Gastroenterology

Yoma 4b ~ Colonic Purging

In the days before Yom Kippur, the Day of Atonement, the Cohen Gadol (High Priest) had to be sequestrated. The sages of the Talmud learn this requirement from Moses himself.

שקלים ד,א

מֹשֶׁה עָלָה בֶּעָנָן, וְנִתְכַּסָּה בֶּעָנָן, וְנִתְקַדֵּשׁ בֶּעָנָן, כְּדֵי לְקַבֵּל תּוֹרָה לְיִשְׂרָאֵל בִּקְדוּשָּׁה, שֶׁנֶּאֱמַר: ״וַיִּשְׁכּוֹן כְּבוֹד ה׳ עַל הַר סִינַי״

Moses ascended in the cloud, and was covered in the cloud, and was sanctified in the cloud, in order to receive the Torah for the Jewish people in sanctity, as it is stated: “And the glory of the Lord abode upon Mount Sinai and the cloud covered him six days, and He called to Moses on the seventh day from the midst of the cloud” (Exodus 24:16).

This verse was interpreted by Rabbi Yossi HaGelili as refering to a period of six days following the verbal giving of the Ten Commandments, during which time Moses prepared himself to receive the Tablets. He was covered by a cloud and sequestrated. It was in memory of that period that all future High Priests would sequestrate themselves in preparation for Yom Kippur.

While agreeing with this interpretation that Moses was sequestered, Rabbi Natan maintained that this verse is not the origin of the model that those who are to enter into the Holiest of Holies and speak with the Divine must be sequestrated. It was a unique requirement that Moses do so, in order that he undergo a rather awkward medical procedure that today is called colonic purging.

שקלים ד,ב

רַבִּי נָתָן אוֹמֵר: לֹא בָּא הַכָּתוּב אֶלָּא לְמָרֵק אֲכִילָה וּשְׁתִיָּה שֶׁבְּמֵעָיו, לְשׂוּמוֹ כְּמַלְאֲכֵי הַשָּׁרֵת

Rabbi Natan says: the verse comes only to purge the food and drink that was in his intestines, to render him like the ministering angels [who require neither food nor drink].

So today let’s talk about colonic purging.

A Brief history of the “Dangerous” colon

Colonic image.jpeg

The idea that our bowels are full of dangerous matter that must be evacuated by means other than the body’s own natural rhythm have been around for a long time. The Egyptians believed that a noxious agent associated with feces was the cause of all disease, and purgatives were prescribed to rid the body of them. The ancient Greek Cnidian School of Medicine owed much to the Egyptians, and taught that disease was caused by food residues that were not properly digested. According to Euryphon who was among those who founded that medical school, “when the belly does not discharge the nutrient that has been taken, residues are produced, which then rise to the regions about the head and cause disease.” In their 1989 paper on the history of the concept of intestinal autointoxiation, the authors note that the second century Greek physician Galen extended the concept of putrefaction to involve not only the residues of food, but also those of bile, phlegm, and blood, incorporating them into their humoral theory of disease.

Among the modern contributors to the idea that a normally functioning colon needs our help was a Ukrainian Jewish immunologist named Élie Metchnikoff (1845-1916.) In 1908 Metchikoff won the Nobel Prize in Medicine for his work on innate immunity, and the discovery that some white blood cells could ingest and destroy harmful pathogens. Along with this, Metchikoff believed that the colon was the source of many of our microbial misfortunes. Here, read it for yourself in his 1906 work The Nature of Man: Studies in Optimistic Philosophy.

From here.

From here.

But the Nobel Prize winner was not correct. The presence of the large intestine in the human body is not the cause of a series of misfortunes, any more than the presence of the lungs causes pneumonia or the presence of the brain causes strokes.

Metchnikoff could be considered an outsider throughout his life, due to his Jewish-Russian origins, his nonmedical training and also in his championing of phagocytosis rather than anti-sera as a primary agent of immunity. He had a prodigious memory and command of scientific literature, but could be paternalistic, sharing in several prejudices of his time. He had a volatile temperament and seemed to enjoy entering into polemics to defend his theories in the face of reasonable and unreasonable objections...
— Siamon Gordon. Elie Metchnikoff, the Man and the Myth. J Innate Immun 2016;8:223–227

What it colonic purging and how is it done?

Colonic purging is the idea that the bowels in general, and the large bowel - the colon - in particular contain toxins and particulate matter that should be artificially evacuated. Doing so, it is claimed, improves overall health. Here for example is how The International Register of Integrative Colon Hydrotherapists and Trainers (RICTAT, “Setting the standards in colonic hydrotherapy”) explains the purpose of a “colonic:”

1. Cleanse the Colon – Toxic material is broken down so it can no longer harm your body or inhibit assimilation and elimination.Debris that has built up over a long period is gently removed in the process of a series of treatments. Once impacted material is removed, your colon can begin to co-operate as it was intended to. In this very real sense, a colonic is a rejuvenation treatment.

2. It Exercises the Colon Muscles – The build-up of toxic debris weakens the colon and impairs its functioning. The gentle filling and emptying of the colon improves peristaltic (muscular contraction) activity by which the colon naturally moves material.

3. It Reshapes the Colon – When problem conditions exist in the colon, they tend to alter its shape which in turn causes more problems. The gentle action of the water, coupled with the massage techniques of the colon therapist helps to eliminate bulging pockets of waste and narrowed, spastic constrictions finally enabling the colon to resume its natural state.

4. It Stimulates Reflex Points – Every system and organ of the body is connected to the colon by reflex points, colonics stimulates these points, thereby affecting the corresponding body parts in a beneficial way.

Wow. Got all that? So a colonic (in this instance a water colonic) gets rid of toxins and debris, exercises the colon, reshapes the colon (whatever that means) and stimulates “reflex points.” In doing so it improves the health of all the various “corresponding body parts.” Lucky Moses!

Should you wish, you can achieve all the above with what RICTAT calls “a ‘Colonic’, ‘Colonic Lavage’, ‘Colonic Irrigation’ or ‘High Colonic’.” The organization claims that “colonic hydrotherapy is [a] safe, effective method for cleansing the colon of waste material by repeated, gentle flushing with water.”

There are a few ways of achieving this “cleansing.” You can, if you are so inclined, have a water enema: “After the gentle insertion of a small tube into the rectum, you are completely covered. Disposable tubing carries clean water in and waste out in a gravity pressured system. The mess and odour sometimes present during an enema simply do not exist with a colonic.” Good to know. Alternatively you can use herbs, laxatives and “dietary supplements” to get all the bad stuff out of your dangerous and nasty colon. Here are some of the more common oral cleansing preparation ingredients together with their proposed mechanisms of action

 
From Acosta and Cash. Clinical Effects of Colonic Cleansing for General Health Promotion: A Systematic Review Am J Gastroenterol 2009; 104:2830–2836.

From Acosta and Cash. Clinical Effects of Colonic Cleansing for General Health Promotion: A Systematic Review Am J Gastroenterol 2009; 104:2830–2836.

 

Do colonics work?

In their helpful 2009 review of the messy business (sorry) of colonics, two gastroenterologists from the National Naval Medical Center in Bethesda, Maryland reviewed all the relevant medical articles they could find relevant articles about colonic cleansing that were published between January 1966 and January 2009. They found almost three hundred articles of potential interest, but only seventeen that met their inclusion criteria which were (i) randomization, (ii) concealed allocation, (iii) double blinding, (iv) complete follow-up of patients, and (v) data reporting in an intention-to-treat analysis. Of these seventeen finalists only two were clinical trials. The others were case reports, case series, and review articles. And none were judged to be of high methodological quality. They were unable to identify

…any published articles describing the effects of colonic hydrotherapy or enema therapy on the promotion of general health or well-being in humans. We were also unable to identify any published reports of the effects of orally administered colonic cleansing therapies for the same outcome. We did identify one study evaluating the effects of colonic cleansing on colonic transit time in patients with chronic constipation. No publications that evaluated the effects of colonic cleansing for any of the conditions previously cited such as hypertension, asthma, irritable bowel syndrome, ulcerative colitis, arthritis, alcoholism, or sinus congestion were identified.

Not one. In over forty years, not one paper in the literature! What a shanda. There was, however, one trial that evaluated the addition of colonic hydrotherapy to accepted medical therapy for the treatment of heroin addiction.

The investigators randomized 75 heroin addicts into two groups: one group was treated with combined dihydroetorphine and methadone therapy, whereas the other group received dihydroetorphine and methadone, as well as colon dialysis (hydrotherapy) with Chinese herbal medicine on days 3–8 of treatment. According to the authors, patients who received hydrotherapy had faster resolution of opiate withdrawal symptoms and achieved a higher rate of abstinence than did the group that did not undergo hydrotherapy. But the methodology of this study is unclear as only the abstract is published in English, and the authors based their conclusions regarding the benefit of hydrotherapy on the rate of cutaneous pigmentation changes, a questionable end point for the stated objectives of this trial.

The Dangers of colonic Cleansing

Are there any dangerous to colonic cleansing? You bet. Here are a few of the choice examples, from the same paper.

  • There have been reports of deaths associated with electrolyte imbalances due to coffee enemas, and there are multiple reports of coffee enema-associated septicemia and colitis.

  • The risk of rectal perforation from colonic irrigation and enema therapy was documented in several reports. One of these reports consisted of three cases of perforation of the rectum from colonic irrigation administered by alternative medicine practitioners in Australia. Each patient in this case series had undergone colonic irrigation to “cleanse” or “clear out stale feces.” None of the patients had primary colonic or rectal pathology. None of the three patients were warned about the complication of perforation. Importantly, one patient initially denied the use of colonic irrigation, even with direct inquiry, presumably because of embarrassment. Another report involved a perforation suffered after a man administered a retrograde enema with a garden hose directly attached to the water source. The patient who suffered a perforation with the garden hose-administered enema suffered from chronic constipation symptoms, although the methods used also raise questions regarding the psychological status of that individual. All of these cases of perforation required surgical intervention.

  • In one of the most striking examples of the risks of colonic hydrotherapy, at least 36 cases of amebiasis occurred in individuals who had undergone colonic-irrigation therapy at a chiropractic clinic in Western Colorado from June 1978 through December 1980. In all, 10 of these patients required colectomy and 6 died.

Another peer reviewed paper by by three physicians from the Georgetown University School of Medicine in Washington, DC noted that there have been reported cases of and pelvic abscesses after colonic hydrotherapy, as well as “fatal aeroportia (gas accumulation in the mesenteric veins) with air emboli, rectal perforations, perineal gangrene, acute water intoxication, coffee enema-associated colitis and septicemia.”

Available scientific evidence does not support the claims on which colon therapy is based. It is known that most digestive processes take place in the small intestine, where nutrients are absorbed into the body. What remains enters the large intestine, where it passes to the rectum for elimination after water and minerals are extracted. Available scientific evidence does not support the premise that toxins accumulate on intestinal walls or that toxicity results from poor elimination of waste from the colon.
— American Cancer Society

The Torah was not given to angels- nor was the colon

Today we are just finally beginning to understand the importance of leaving the bowel alone, and not upsetting its fragile ecosystem with unnecessary antibiotics or silly colonic enemas. At the same time there is an appreciation that perhaps the gut plays a role in our health to a far greater degree than we once realized. (The ancient Egyptians would have been proud). In a 2019 review, researchers pointed out that the gut microbiome influences all sorts of things, including the central nervous system.

There is much to learn and the field is young, but even at this stage it is clear that the many bacteria, viruses, and fungi in the healthy gut live there in a careful balance. The less we upset that balance, the better. In several places in the Talmud, the rabbis reminded us that “The Torah was not given to angels” (לא ניתנה תורה למלאכי השרת). It might be a good time to remember that the colon was not given to angels either. Unlike angels, we need our colons intact and un-purged. Indeed, our lives depend on it.

From Mishori, R. The dangers of colon cleansing. The Journal of Family Practice. 2011: 60 (8):454-457.

From Mishori, R. The dangers of colon cleansing. The Journal of Family Practice. 2011: 60 (8):454-457.

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Shekalim 13a-b ~ The Cohen and his Stomach Problems

On page 13 of Shekalim we read about the fifteen Temple officers and the administrators who held them:

שקלים טו, א

…אֵילּוּ הֵן הַמְמוּנִּין שֶׁהָיוּ בַּמִּקְדָּשׁ. יוֹחָנָן בֶּן פִּינְחָס עַל הַחוֹתָמוֹת. אֲחִייָה עַל הַנְּסָכִים. מַתְיָה בֶּן שְׁמוּאֵל עַל הַפְּייָסוֹת…בֶּן אֲחִייָה עַל חוֹלֵי מֵעַיִם

These are the officials who served in specific positions in the Temple: Yochanan ben Pinchas was responsible for the seals. Achiyya was responsible for the libations, while Ben Achiyya was responsible for the treatment of those Cohanim who had an intestinal disorder…

The Talmud then explains the nature of these intestinal disorders:

שקלים טו, ב

בֶּן אֲחִייָה עַל חוֹלֵי מֵעַיִם. עַל יְדֵי שֶׁהָיוּ הַכֹּהֲנִים מְהַלְּכִין יְחֵיפִים עַל הָרִצְפָּה וְהָיוּ אוֹכְלִין בָּשָׂר וְשׁוֹתִין מַיִם הָיוּ בָאִין לִידֵי חוֹלֵי מֵיעַיִם. וַהֲוָה יְדַע אֲהֵײ דֵין חֲמַר טַב לִמְעַייָא. וְהֵיי דֵין חֲמַר סְמַס לִמְעַייָא

Clostridial diarrheal infections. Meat dishes left to cool at room temperature grow large numbers of clostridia. When contaminated meat is ingested, C. perfringens types A and C produce alpha-enterotoxin in the small intestine during sporulation, ca…

Clostridial diarrheal infections. Meat dishes left to cool at room temperature grow large numbers of clostridia. When contaminated meat is ingested, C. perfringens types A and C produce alpha-enterotoxin in the small intestine during sporulation, causing abdominal pain and diarrhea. Type C also produces beta-enterotoxin botulism. From Harwood-Nuss’ Clinical Practice of Emergency Medicine. Kluwer 2021. Chap 115.

Ben Achiyya was appointed to treat those priests who suffered from intestinal disease: Since the priests would walk barefoot on the floor [even when it was cold, as their feet had to be in contact with the stones of the Temple floor,] and since they would eat a lot of meat from the offerings and drink a lot of water, they would contract intestinal disease. And Ben Achiyya knew that which particular type of wine was good for healing the intestines, and which type of wine was would be bad for the bowels.

Pity the Poor Cohen

It would seem then, that an upset stomach was one of the perils of the job for a Cohen called to service in the Temple. Elsewhere we have noted that the tribe of the Cohanim (pl. of Cohen) were likely to suffer from a number of different ailments including vertical diplopia (most commonly caused by damage to the fourth cranial nerve, called the trochlear nerve), nystagmus, liver disease (with gynecomastia, ascites and testicular atrophy) and depression. Some also had syndactyly, a condition in which some of the fingers or toes are fused together. That condition is genetic, but some of the other Cohen associated ailments can be explained by chronic alcohol misuse.

The causes of Gastroenteritis

It would seem that when they came to Jerusalem to serve, the Cohanim would often contract gastroenteritis, an inflammation of the gastrointestinal tract. It is a common set of conditions, and I must have treated many hundreds of people with the condition over my decades as an emergency physician (though even when working in Jerusalem, I never once made the association with the Temple service, nor asked if the patient has the risk factor of being a Cohen. Woops). The patient feels weak, and there is vomiting and loose or watery diarrhea. If the patient does not (or cannot) drink enough fluids, she can become dehydrated, and feel dizzy. In most cases the condition is self-limiting, and lasts only a day or so.

There are dozens and dozens of causes of gastroenteritis, most of which are viral. Sometimes the infectious agent produces a toxin on foods which is then ingested. In other cases the toxin is produced once the virus or bacteria have been ingested, though it doesn’t make much difference to the patient in the ER. Or the Cohen in the Temple.

Mechanisms of infectious diarrhea illness. Note that pathogens can produce an enterotoxin in food prior to ingestion. That is what gives you food poisoning. They can also produce a toxin in the intestines after ingestion, which can cause a non-blood…

Mechanisms of infectious diarrhea illness. Note that pathogens can produce an enterotoxin in food prior to ingestion. That is what gives you food poisoning. They can also produce a toxin in the intestines after ingestion, which can cause a non-bloody diarrhea (e.g., V. cholerae) or bloody diarrhea (e.g., C. difficile). From From Harwood-Nuss’ Clinical Practice of Emergency Medicine. Kluwer 2021. Chap 115.

And here, for your delight is a list of some of the agents that cause gastroenteritis, and which Ben Achiyya would have had to treat. With wine.

F=Fever, AP= Abdominal Pain, NV=Nausea and vomiting, BD= Blood diarhhea. From From Harwood-Nuss’ Clinical Practice of Emergency Medicine. Kluwer 2021. Chap 159.

F=Fever, AP= Abdominal Pain, NV=Nausea and vomiting, BD= Blood diarhhea. From From Harwood-Nuss’ Clinical Practice of Emergency Medicine. Kluwer 2021. Chap 159.

Walking Barefoot, Eating meat and Gastroenteritis

In today’s page of Talmud, the upset stomachs suffered by the Cohanim is blamed on three things: walking barefoot, eating meat and drinking water. Let’s take a look and figure out if what, culpability if any, each of these had.

  1. Walking Barefoot - מְהַלְּכִין יְחֵיפִים עַל הָרִצְפָּה

    Can walking barefoot lead to gastroenteritis? No. So that is easy.

  2. Eating Meat - אוֹכְלִין בָּשָׂר

    Is there a relationship between eating meat and gastroenteritis? Why yes, certainly there is. In the table above you can see that a bacteria called Yersinia is a common etiological agent. Among its favorite hiding places are raw and undercooked meat, especially if that meat was contaminated with urine or feces. According to the CDC, “Y. enterocolitica causes almost 117,000 illnesses, 640 hospitalizations, and 35 deaths in the United States every year. Children are infected more often than adults, and the infection is more common in the winter.” Another bacteria that can cause a meat related enteritis is salmonella (though it is more commonly associated with eggs and poultry). As the World Health Organization likes to remind us:

    Salmonella bacteria are widely distributed in domestic and wild animals. They are prevalent in food animals such as poultry, pigs, and cattle; and in pets, including cats, dogs, birds, and reptiles such as turtles. Salmonella can pass through the entire food chain from animal feed, primary production, and all the way to households or food-service establishments and institutions.

  3. Drinking Water - וְשׁוֹתִין מַיִם

    Contaminated drinking water is a well-established and still very prevalent cause of acute gastroenteritis. In a review of the problem published in Water and Health, the authors note that “transmission by food or water has been documented for astroviruses, caliciviruses, rotaviruses, and norovirus…Conservative estimates put diarrhea in the top five causes of deaths worldwide with 3.5 to 5 million deaths every year and most occurring in young children in non-industrialized countries. According to the World Health Organization (WHO), diarrheal diseases account for 4.1 % of the total DALY global burden of disease of which 88% is attributable to unsafe water supply, sanitation, and hygiene.”

    In tractate Yoma (19a) we learn that all of the water in the Temple came from but a single well, known as the בור הגולה – “The Well of the Diaspora.” That was a dangerous practice since should it become contaminated, everyone who drank from it could become sick. It would have been better (from a public health perspective) for some of those who served in the Temple to have used a second water source.

    Here are just some of the the nasty pathogens that can contaminate the water supply.

From Griffiths, J. Waterborne Diseases. In The International Encyclopedia of Public Health, 2nd edition, Volume 7, 395.

From Griffiths, J. Waterborne Diseases. In The International Encyclopedia of Public Health, 2nd edition, Volume 7, 395.

The Prohibition against eating Sacrificial Meat left out for too long

It is interesting to note that there is a biblical prohibition called Nossar (נותר) against eating sacrificial meat outside of its proscribed time. The Torah outlines the prohibitions in several places. Here are some of them:

The Paschal Lamb (Ex. 12.10):

וְלֹא־תוֹתִ֥ירוּ מִמֶּ֖נּוּ עַד־בֹּ֑קֶר וְהַנֹּתָ֥ר מִמֶּ֛נּוּ עַד־בֹּ֖קֶר בָּאֵ֥שׁ תִּשְׂרֹֽפוּ׃

You shall not leave any of it over until morning; if any of it is left until morning, you shall burn it.

The Festival Offering (Deut. 16:4)

וְלֹא־יָלִ֣ין מִן־הַבָּשָׂ֗ר אֲשֶׁ֨ר תִּזְבַּ֥ח בָּעֶ֛רֶב בַּיּ֥וֹם הָרִאשׁ֖וֹן לַבֹּֽקֶר׃

For seven days no leaven shall be found with you in all your territory, and none of the flesh of what you slaughter on the evening of the first day shall be left until morning.

The Thanksgiving Offering (Lev. 22:30)

בַּיּ֤וֹם הַהוּא֙ יֵאָכֵ֔ל לֹֽא־תוֹתִ֥ירוּ מִמֶּ֖נּוּ עַד־בֹּ֑קֶר אֲנִ֖י ה׳׃

It shall be eaten on the same day; you shall not leave any of it until morning: I am the LORD.

The Shelamim Offering (Lev. 7:15)

וּבְשַׂ֗ר זֶ֚בַח תּוֹדַ֣ת שְׁלָמָ֔יו בְּי֥וֹם קָרְבָּנ֖וֹ יֵאָכֵ֑ל לֹֽא־יַנִּ֥יחַ מִמֶּ֖נּוּ עַד־בֹּֽקֶר׃

And the flesh of his thanksgiving sacrifice of well-being shall be eaten on the day that it is offered; none of it shall be set aside until morning.

Meat that is properly roasted is less likely to contain pathogens or toxins that cause gastroenteritis. But in a Middle-Eastern climate and without refrigeration, that meat would very quickly spoil and become contaminated with all sorts of pathogens. From the perspective of good food hygiene, disposing of it within a few hours of cooking was an extremely important measure to prevent the kinds of illnesses the Cohanim seemed to catch all too often. And the while the wine that Ben Achiyya could not cure any gastroenteritis, at least its alcohol content meant that it was itself not likely to contain the pathogens found in natural water supplies.

From the very
beginning there has been something unhealthy about these priestly aristocracies and in the customs dominant there, which are turned away from action and are partly brooding and partly emotionally explosive, resulting in the almost inevitable bowel complaints and neurasthenia which have plagued the clergy down the ages
— Friedrich Neitzsche. On the Genealogy of Morality. Cambridge University Press 2007. p16.

Today, we take proper food hygiene for granted, and are fastidious about washing both our hands and our food. We expect meat and vegetables to be free of bacteria, and when there are outbreaks of food-born illnesses they often make the national news, like one did just two days ago. We take such luxuries for granted, but as today’s page of Talmud reminds us, we should not do so. For much of the world’s population, clean drinking water and plentiful safe food are still not guaranteed. Be grateful for your plenty, and be grateful that you did not need to serve as a Cohen in the Temple.

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