Avodah Zarah 3b ~ Heliotherapy

The first few pages of the new tractate we are learning, Avodah Zarah addresses the punishment that awaits those wicked nations that persecuted the Jewish people.  Then comes this parable:

עבודה זרה  ג,ב–ד,א 

דאמר רבי שמעון בן לקיש אין גיהנם לעתיד לבא אלא הקדוש ברוך הוא מוציא חמה מנרתיקה  ומקדיר. רשעים נידונין בה וצדיקים מתרפאין בה. רשעים נידונין בה... צדיקים מתרפאין בה  דכתיב וזרחה לכם יראי שמי שמש צדקה ומרפא בכנפיה אלא שמתעדנין בה שנאמר ויצאתם ופשתם כעגלי מרבק

As Rabbi Shimon ben Lakish says: There is no Gehenna in the World-to-Come. Rather, the Holy One, Blessed be He, will remove the sun from its sheath [minnarteikah], and heats [umakdir]that world with it. The wicked will be punished by it and consumed by the heat, but the righteous will be healed by it....moreover, not only will they be healed by it, but they will even be rejuvenated by it, as it is stated in the continuation of that verse (Malachi 3:20) “And you shall go forth and leap as calves of the stall.”

Other mentions of the sun as medicine

We met the same homily in the name of Resh Lakish when we studied Nedarim 8b. Elsewhere (Bava Basra 16b) we read a teaching of Abaye that also addresses the healing power of the sun:

בבא בתרא טז, ב

רבי שמעון בן יוחי אומר אבן טובה היתה תלויה בצוארו של אברהם אבינו שכל חולה הרואה אותו מיד מתרפא ובשעה שנפטר אברהם אבינו מן העולם תלאה הקדוש ברוך הוא בגלגל חמה אמר אביי היינו דאמרי אינשי אידלי יומא אידלי קצירא

Rabbi Shimon ben Yochai said: there was a precious stone that hung from the neck of Abraham our forefather. Any sick person who looked at it was instantly cured.  When Abraham our forefather died, the Holy One, Blessed be He, hung this stone in the orb of the sun. Abaye said, this is what is meant by the popular saying "when the sun is lifted, sickness is lifted"
Image of the sun.jpg

We know not to take homilies literally, but it turns out that Resh Lakish (c.200 CE) and Abaye (d~339 CE) were on to something when they taught that the sun heals.   

A History of Heliotherapy

In 1903, the Nobel prize for Medicine was awarded to a Dane named Niels Finsen. Finsen had invented a focusable carbon-arc torch to treat – and cure – patients with lupus vulgaris, a painful skin infection caused by tuberculosis.  While this was the start of the modern medical use of phototherapy, using the sun as a source of healing is much, much older. Older even than the Talmud, which mentions it in today’s daf

The Nobel Prize in Physiology or Medicine 1903 was awarded to Niels Ryberg Finsen “in recognition of his contribution to the treatment of diseases...with concentrated light radiation, whereby he has opened a new avenue for medical science”.

Perhaps the earliest reference to heliotherapy – that is, using sunlight to heal - is found in Egyptian papyrus records from over 3,500 years ago, which record using the sun, together with ingesting a local weed, to treat skin conditions. The active ingredients of that weed, Ammi majus, were isolated in 1947. These ingredients, together with heliotherapy, were used in the first clinical trials to treat vitiligo, which were conducted, rather fittingly, in Egypt.  Further work determined that it was only a narrow part of the sun’s spectrum that was needed to treat vitiligo, psoriasis, and other skin conditions, and so lamps were developed that produced only narrow band ultraviolet light (UVB). These UVB lamps are now a mainstay of treatment for psoriasis. 

Sunlight for Healthy Bones

For most white people, a half-hour in the summer sun in a bathing suit can initiate the release of 50,000 IU (1.25 mg) vitamin D into the circulation within 24 hours of exposure
— Environmental Health Perspectives 2008:116;4. A162

But ultraviolet light – UVB – can also be extremely dangerous. Too much exposure to sunlight will cause skin cancer, as the light produces molecules that directly damage DNA. Here is the great paradox of sunlight – too much of it will burn and can kill – but get the dose right and it is not only curative, but essential for healthy living. Sunlight is needed to produce vitamin D in the skin, and vitamin D is needed to produce healthy bones. Without it, you will develop rickets, a skeletal deformity that is characterized by bowed legs. 

Typical presentation of 2 children with rickets. The child in the middle is normal; the children on both sides have severe muscle weakness and bone deformities, including bowed legs (right) and knock knees (left). From Holick M. Sunlight and vi…

Typical presentation of 2 children with rickets. The child in the middle is normal; the children on both sides have severe muscle weakness and bone deformities, including bowed legs (right) and knock knees (left). From Holick M. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular diseaseAm J Clin Nutr 2004;80(suppl):1678S–88S.

Sunlight for a Healthy Immune System

The sun’s light has been shown to have effect the immune system, although many of these effects are only poorly understood. 

When some nerve fibres are exposed to sunlight, they release a chemical called neuropeptide substance P. This chemical seems to produce local immune suppression.  Exposure to the ultraviolet wavelengths in sunlight can change the regulation of T cells in the body which can also modulate autoimmune diseases.

Sunlight to Treat Melanoma?

While sunlight can cause skin cancer, it has been shown to release a hormone called alpha melanocyte-stimulating hormone. This hormone appears to limit the damage to DNA damage from sunlight and so may actually reduce the risk of melanoma (but don't try this as a treatment yet. It's certainly not ready for prime time.)

Sunlight for Your Mood

Then there’s sunlight for your mood. Seasonal affective disorder – SAD – is caused by a lack of exposure to sunlight, which most affects those living in the northern latitudes in the winter.  SAD was first described in 1984 by Norman Rosenthal working at the National Institute of Mental Health but why it happens is still something of a mystery.  Rosenthal went on to write several best selling books on SAD and how to beat it. The answer appears to be something to do with sitting in front of a lamp that mimics sunlight (but the evidence that this works is still controversial).

 Sunlight for Babies with Jaundice

Sunlight is also a great treatment for babies with neonatal jaundice. This condition is very common and is caused when the baby breaks down the fetal hemoglobin with which it was born. A product of that breakdown is bilirubin, and if this is allowed to build up in the tissues it can cause lethargy, difficultly feeding, and in rare and extreme cases, brain damage. However, sunlight (or more precisely, the blue band of the spectrum at 459nm)  breaks down this dangerous bilirubin molecule into a harmless one called biliverdin.  So the best treatment for a newborn baby with mild jaundice is to put them out in the sun.  (Failing that, or if the degree of jaundice is not mild, you can consider phototherapy in the hospital.) 

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The absorbance spectrum of bilirubin bound to human serum albumin (white line) is shown superimposed on the spectrum of visible light. Clearly, blue light is most effective for phototherapy, but because the transmittance of skin increases with increasing wavelength, the best wavelengths to use are probably in the range of 460 to 490 nm. Term and near-term infants should be treated in a bassinet, not an incubator, to allow the light source to be brought to within 10 to 15 cm of the infant (except when halogen or tungsten lights are used), increasing irradiance and efficacy. For intensive phototherapy, an auxiliary light source (fiber-optic pad, light-emitting diode [LED] mattress, or special blue fluorescent tubes) can be placed below the infant or bassinet. If the infant is in an incubator, the light rays should be perpendicular to the surface of the incubator in order to minimize loss of efficacy due to reflectance. From Maisels and McDonagh. Phototherapy for Neonatal JaundiceNew England Journal of Medicine 2008.358;920-928.

Sunlight for Infectious Diseases

 We don't treat infectious diseases with sunlight any more. But it wasn't always that way. Less than eighty years ago sunlight was recommended as a therapy for some patients with tuberculosis. The authors, writing in the journal Diseases of the Chest were cautious:

Even in those cases where the sun can be of great value, it is in no sense a specific cure for any manifestation of tuberculosis. Rest, good food, and fresh air, are still the fundamentals in treating all forms of the disease; and the sun, where it should be used, is only a valuable adjutant...Heliotherapy is not indicated in all cases of tuberculosis. The majority of patients with this disease should never use it...It is not a sure cure for any type of tuberculosis, but is often, especially in some of the extrapulmonary cases, a very valuable—or even necessary—aid.

In today's daf, Resh Lakish taught that sun can both reward and punish. His insight was more correct than he could ever have imagined.  

Bright light therapy and the broader realm of chronotherapy remain underappreciated and underutilized, despite their empirical support. Efficacy extends beyond seasonal affective disorder and includes nonseasonal depression and sleep disorders, with emerging evidence for a role in treating attention-deficit/hyperactivity disorder, delirium, and dementia.
— Schwartz and Olds. The Psychiatry of Light. Harvard Review of Psychiatry 2015. 23 (3); 188.

[Mostly a repost from Bava Basra 16 and Nedarim 8.]

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Tractate Avodah Zarah ~ Which Version Do You Use?

Censored Image.png

Today marks the start of a new tractate in the Daf Yomi cycle: Avodah Zarah, which largely deals with the relationships Jews may and may not have with their idol worshiping neighbors. While most of these neighbors are described as idol worshipers or heretics, in at least three places the text refers to them as נוצרים - Christians. 

The problem is that you might never know this if you are using the censored version of the Talmud.  Over the centuries, this version became the standard Hebrew text. It is found in nearly all editions based of the so-called "Vilna Shas" edition, first published by The Widow and Brothers Romm in 1886.  It is also the basis for the text used in the Schottenstien Talmud.

Censorship in Masechet Avodah Zarah

Consider this section from Avodah Zarah 6a, which discusses rules about business dealings. As you can see, the standard text makes no mention of with whom we may not do business on a Sunday. In the Schottenstein (Art Scroll) edition the translation adds this explanation: It refers to "Babylonian pagans who observe a sun-worshipping festival every Sunday."

 
Schottenstein 6a.png
 

Except, it doesn't. Or at least it didn't. Here is the same text found in a 14th century manuscript, from the Bibliotheque Nationale in Paris (Suppl. Heb 1337).

Avodah Zara נוצרי Bibliotheque detail.png

The text reads: 

אמ[ר] שמואל נוצרי לדברי ר[בי] ישמע[אל] לעולם אסור

Shmuel says: According to Rabbi Yishmael, it is always prohibited to engage in business with Christians, [as their festival takes place every Sunday].

In the original, pre-censored Talmudic text, it is Christians with whom we are forbidden to do business on a Sunday. Not Babylonian pagans. The more recent Koren Talmud restores the text to its original:

Koren 6a detail.jpg

There are at least two other instances in Avodah Zarah (6a and 7b) in which the Koren Talmud restores  the text and uses the word Christian.  Later on (17a,) an entire passage containing the words ישו הנוצרי - Jesus of Nazereth has been redacted.  It can be found in the restored Koren edition:

Koren Avodah Zarah 17a

Koren Avodah Zarah 17a

The Truth and Its Consequences

Using the original uncensored text raises its own set of uncomfortable questions about our original relationship to Christianity. But using the censored text can lead to some silly outcomes. Here is an example, (based on a review essay of the Koren Talmud I wrote here).

The text of the Talmud in Berachot 3a describes God sitting through the night, mourning the loss of his Temple.  The original uncensored text reads:

 אוי לי שהחרבתי את ביתי ושרפתי את היכלי והגליתים לבין אומות העולם

Woe is me, for I destroyed my Temple, and I burned my Sanctuary, and I exiled them among the nations of the world.

However, the text of the English Schottenstein (and the Soncino) edition reads as follows: 

אוי לבנים שבעונותיהם החרבתי את ביתי ושרפתי את היכלי והגליתים לבין אומות העולם

Woe to the children, because of whose sins I destroyed my Temple, and I burned my Sanctuary, and I exiled them among the nations of the world.

The additional words  לבנים שבעונותיהם were added by Christian censors to make a theological statement about the fallen state of the Jews.  The corrupted text was noted in Dikdukei Soferim, but none of this seems to have been evident to the editors of the English Schottenstein Talmud, who compounded the error by adding the following homiletic note to the corrupted text.

Detail from Schottenstein English Talmud Berachot 3a.

Detail from Schottenstein English Talmud Berachot 3a.

In its effort to comment on (nearly) everything, the Schottenstein edition added a homiletic explanation of a corrupt text written (almost certainly) by a Jewish apostate serving as Christian censor. Fortunately, the Hebrew and English editions of the Koren, together with the Hebrew edition of the Schottenstein (ArtScroll) Talmud returned the text to its original and uncensored form. No homiletic gymnastics needed.

Where did Avodah Zarah Go?

One of the early editions of Talmud was printed in Basel in 1580.  According to Marvin Heller, (who knows everything about early Hebrew printing and the printing of the Talmud) it was "the most heavily censored edition of the printed Talmud. One tractate, Avodah Zarah was entirely omitted, the name alone being sufficient to disqualify it."

There were Christian censors to be sure.  But Elisheva Carelbach, in her essay The Status of the Talmud in Early Modern Europe, notes that ironically, the Talmud may have been spared further decimation because of the intercession of Christian scholars:

In the aggregate, the positive interest of the hebraists paved the way for the printing and survival of the Talmud in Europe by assuring Europe’s rulers of its value. Christian talmudists set the foundations for the modern academic study of the Talmud. The preservation and study of the Talmud by Christian scholars in any measure might be regarded as one of the small miracles of the early modern period.
— Elisheva Carelbach. The Status of the Talmud in Early Modern Europe. In Mintz and Goldman (eds). Printing the Talmud: From Bomberg to Schottenstein. Yeshiva University Museum 2005. p88.

So now, as we embark on the study of tractate Avodah Zarah, which edition will you be using? And which edition should you be using?

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Shavuot 25a ~ How Long Can You Go Without Sleep?

שבועות כו, א

והא"ר יוחנן שבועה שלא אישן שלשה ימים מלקין אותו וישן לאלתר

...Rabbi Yochanan said "An oath that I will not sleep for three days" - we lash him [since he took an oath in vain] and he may sleep immediately...(Shavuot 26b)

How long can you go without sleep? If you are like me, staying awake for just one night can be very challenging.  I worked my share of night shifts in the emergency department for over fifteen years (amounting to hundreds of overnight shifts) but it never got any easier with time. We all push ourselves when we need to, but is there a physiological limit to the amount of time that you can stay awake? Rabbi Yochanan ruled that it was impossible to remain awake for more that three days. What does science have to say?

The World Record for Staying Awake

The world record for staying awake is an amazing eleven days. Eleven days – that’s 264 hours (and 24 minutes to be precise) without sleep. It was set in 1965 by Randy Gardner, who was then seventeen years old. Gardner seems to have suffered little if any harm by his marathon period of sleep deprivation. But don’t try and beat the record. The Guinness Book of Records no longer has an entry for staying awake – because it is considered too dangerous an ordeal to undertake. (You can hear a review of sleep deprivation stunts in general and a wonderful interview with Gardner himself here.)

The Health Risks of Sleep Deprivation

A 1970 study of four volunteers who stayed awake for 205 hours (that’s eight and a half days!) noted some differences in how the subjects slept once they were allowed to do so, but follow-up testing of the group conducted 6-9 months after the sleep deprivation showed that their sleep patterns were similar to the pre-deprivation recordings.

Although Randy Gardner and these four volunteers seem to have suffered no long-term health consequences of staying awake for over a week, scientists have long noted that sleep deprivation is rather bad for the body. Or to be more precise, the bodies of unfortunate laboratory rats who are not allowed to sleep. In these animals, prolonged sleep deprivation causes the immune system to malfunction. This results in infection and eventual lethal septicemia. The physiologist who kept these rats awake noted that there are “far-reaching physical implications resulting from alterations in immune status [which] may explain why sleep deprivation effects are risk factors for disease and yet are not well defined or specifically localized.” In other words, sleep deprivation makes rats really sick, but we don’t know how, or why…

One possible explanation was suggested in a 2013 by a group from the University of Rochester Medical Center. They demonstrated that during sleep, the space between the cells of the brain (the interstitial space) increased by up to 60%, allowing toxic metabolites to be cleared. This raises the question of whether the brain sleeps in order to expel these toxic chemicals, or rather it is the chemicals themselves that drive the brain to switch into a sleep state.

The extracellular (interstitial) space in the cortex of the mouse brain, through which cerebral spinal fluid moves, increases from 14% in the awake animal to 23% in the sleeping animal, an increase that allows the faster clearance of metabolic waste…

The extracellular (interstitial) space in the cortex of the mouse brain, through which cerebral spinal fluid moves, increases from 14% in the awake animal to 23% in the sleeping animal, an increase that allows the faster clearance of metabolic waste products and toxins. From Suzana Herculano-Houzel. Sleep it out. Science 2013: 342; 316

Not having any sleep is bad for your health - but so too is going without enough sleep. Chronic restriction of sleep to six hours or less per night can produce cognitive performance deficits equivalent to up to two nights of total sleep deprivation. So be sure to get a full night's rest.

How long did the Vilna Gaon stay awake?

In his recent book on the Vilna Gaon, Eli Stern reviewed an episode in which the Gaon (d. 1797) was jailed on charges of kidnapping. (It’s a long story, but the Vilna Gaon was involved in the kidnapping of a young Jewish man who had converted to Christianity.) This episode occurred in January 1788, after which the Gaon was arrested and held for over a month.  The case was later tried, and on September 15, 1789 (sic) the Gaon of Vilna (together with others involved in the kidnapping) was sentenced to twelve weeks in jail.  Although it is unclear how long he was imprisoned, he was there over Sukkot, and the Lithuanian authorities were hardly in the practice of providing imprisoned Jews with a sukkah.  But since one is not permitted to sleep outside of the sukkah, what was the Gaon to do?  Simple.  He’d stay awake, and by doing so he would not transgress the prohibition of sleeping outside the sukkah.  Here’s how the episode is described in the work Tosefet Ma’aseh Rav published in 1892. 

Our Leader, teacher and Rabbi may he rest in peace, when he was imprisoned on Sukkot, tried with all his strength, and walked from one place to another, and held his eyelids open, and made an extraordinary effort not to sleep outside the sukkah – not even a brief nap – until the authorities released him to a sukkah.

We don’t know for how long the sixty-nine year-old Elijah stayed awake, but any suggestion that he was awake for the entire holiday of Sukkot seems to be far fetched (though as we have seen, not entirely impossible).

Hard, But Not Impossible

In tomorrow's daf, Rabbi Yochanan ruled that since it impossible to stay awake for more than three days, any vow to do so is considered to have been a vow made in vain – and punishment follows swiftly.  Here is how the ArtScroll Talmud explains this ruling, (based on the explanation of the Ran).

Since it is impossible for a person to go without sleep for three days, the man has uttered a vain oath. Hence, he receives lashes for violating the prohibition (Exodus 20:7): לא תשא את שם ה׳ אלוקיך לשוה, You shall not take the Name of Hashem, your God, in vain. And since the oath -being impossible to fulfill -has no validity, he is not bound by it at all and may sleep immediately.

We have seen however, that while it’s not a good idea to do so on any kind of regular basis, it is certainly possible to stay up for longer than three days. (Back in the 1970s, some volunteers would even do so for as little as $100). Maimonides codified this law and also assume that it is impossible to stay awake for three consecutive days. 

רמב"ם הלכות שבועות פרק ה הלכה כ

נשבע שלא יישן שלשת ימים, או שלא יאכל כלום שבעת ימים וכיוצא בזה שהיא שבועת שוא, אין אומרין יעור זה עד שיצטער ויצום עד שיצטער ולא יהיה בו כח לסבול ואח"כ יאכל או יישן אלא מלקין אותו מיד משום שבועת שוא ויישן ויאכל בכל עת שירצה

Based on what we've reviewed, Rabbi Yochanan was incorrect when he stated that it was impossible to stay awake for three days. It's certainly not impossible, but that hardly means it's a good idea to try. 

This may explain the teaching of Rabbi Chaninah ben Chachina'i in Masechet Avot  (3:4) who taught that one who stays awake at night "will forfeit with his life."  Now that's a warning to heed.

רבי חנינא בן חכינאי אומר הנעור בלילה ... הרי זה מתחייב בנפשו 

Sleep deprivation reduces learning, impairs performance in cognitive tests, prolongs reaction time, and is a common cause of seizures. In the most extreme case, continuous sleep deprivation kills rodents and flies within a period of days to weeks. In humans, fatal familial or sporadic insomnia is a progressively worsening state of sleeplessness that leads to dementia and death within months or years.
— Lulu Xie et al. Sleep Drives Metabolite Clearance from the Adult Brain. Science 2013. 342.317

[Repost from NedariM 15]

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Shavout 18b ~ The regularity of the menstrual cycle

שבועות יח, ב

ת"ר "והזרתם את בני ישראל מטומאתם" אמר רבי יאשיה מיכן אזהרה לבני ישראל שיפרשו מנשותיהן סמוך לוסתן וכמה אמר רבה עונה 

Our Rabbis taught: "You shall separate the children of Israel from their uncleanness"[Lev. 15:31]; R.
Yoshiah said: From this we deduce a warning to the children of Israel that they should separate from
their wives near their periods. And how long before? Rabbah said: One ‘onah [either the whole day or the whole night].

From here.

From here.

In tomorrow's page of Talmud, Rabbah (~270-330 CE), who lived in Babylonia, ruled that a couple must refrain from intercourse if menstruation is expected to begin within a twelve hour window.  This ruling is included in the Shulchan Aruch, the code of Jewish Law, as the required Jewish practice:

שולחן ערוך יורה דעה קפד, ב

בִּשְׁעַת וִסְתָּהּ, צָרִיךְ לִפְרֹשׁ מִמֶּנָּהּ עוֹנָה אַחַת, וְלֹא מִשְּׁאָר קְרִיבוּת אֶלָּא מִתַּשְׁמִישׁ . אִם הוּא בַּיּוֹם, פּוֹרֵשׁ מִמֶּנָּהּ אוֹתוֹ הַיּוֹם כֻּלּוֹ אֲפִלּוּ אִם הַוֶּסֶת בְּסוֹפוֹ, וּמֻתָּר מִיָּד בַּלַּיְלָה שֶׁלְּאַחֲרָיו, וְכֵן אִם הוּא בִּתְחִלָּתוֹ, פּוֹרֵשׁ כָּל הַיּוֹם וּמֻתָּר כָּל הַלַּיְלָה שֶׁלְּפָנָיו

During her veset, [the expected onset of menstruation, her husband] must separate from her for one onah, not from all contact but only from marital relations. If her period is expected in the daytime, separate from her for that entire day, even if the veset is at the end of the day, and it is permitted [to have marital relations] immediately the following evening. Similarly, if [the veset] is at the beginning, separate the whole day and it is permitted the entire preceding evening...

This ruling suggests that women can predict when the onset of menses will be. How often is that in fact the case? Well, for the half of you who are men, it might surprise you to learn that this ability to predict the onset is less common than you would think. Women, I am sure, already know this.  

How Regular is Regular?

In a 2011 review paper "The normal menstrual cycle in women," the authors point out that the 28 day"text-book" length of the menstrual cycle in young healthy women is in fact highly variable. Even between similarly aged women the cycle may range from 25 to 34 days. More to our topic, there are many women in whom the cycle length changes. In those aged around twenty, about 47% of women have a variation by as much as 14 days annually.  

Variation of menstrual cycle length as a function of age in the woman. This graph shows mean cycle length and the range (5th and 95th percentile) reported in 4 studies. yrs = years, d = days. Triangles indicate the age group in which the indicated p…

Variation of menstrual cycle length as a function of age in the woman. This graph shows mean cycle length and the range (5th and 95th percentile) reported in 4 studies. yrs = years, d = days. Triangles indicate the age group in which the indicated percentage of women shows more than 14 days variation in cycle length annually. From M. Mihma, S. Gangooly, S. Muttukrishnab. The normal menstrual cycle in women. Animal Reproduction Science 124 (2011) 229–236.

Another study on the variability of menstrual length from one cycle to the next comes from the Obstetrics and Gynecology Department at the University of Pittsburgh.  They asked 130 women to keep menstrual diaries and record their menstrual flow for at least four menstrual cycles and for as long 30 weeks. 

Participants prospectively recorded their menses for the up to 30 weeks. Each subject’s estimated cycle length was compared to the average of her actual cycle lengths and the range and variability in each individual’s cycle length was calculated. A total of 786 cycles from 130 women who recorded 4 or more cycles were analyzed.

They found that 46% of all subjects had a cycle range of 7 days or more, and 20% had a cycle range of 14 days or more. In other words, almost half of the women had a cycle-to-cycle change of at least a week, and one in five had a change of two weeks or more.  "Therefore" they wrote, "one out of every five subjects who reported that they had regular cycles were experiencing periods that occurred 1 week away from the expected date."

Irregularity in Jewish Law

For those who wish to learn more, there is a long section in the Shulchan Aruch (יורה דעה הל׳ נידה  קפט) that addresses the complicated issue of irregular menses and the required time for a husband and wife to refrain from intercourse. This long section is needed because for many (?most) women, the length of the menstrual cycle changes from one period to the next. R. Yoshia's ruling that a couple must refrain from marital relations "סמוך לוסתן"  - at the expected time of menstruation -  turns out to be a rather complicated thing to do.  

This study establishes that “regular” menstrual cycles are quite variable from cycle to cycle. The inherent variability in menstrual cycle length, which is likely a function of when ovulation occurs, must be studied prospectively to understand its full impact on contraceptive research trials and pregnancy-related care.
— Crenin, M.D. Keverline, S. Meyen, L.A. How regular is regular? An analysis of menstrual cycle regularity. Contraception 2004:70;289-292
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